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LEA motifs promote desiccation tolerance in vivo by Hibshman, Jonathan D. (author);Goldstein, Bob (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is LEA motifs promote desiccation tolerance in vivo about?

## Background: Cells and organisms typically cannot survive in the absence of water. however, some animals including nematodes, tardigrades, rotifers, and some arthropods are able to survive near-complete desiccation. one class of proteins known to play a role in desiccation tolerance is the late embryogenesis abundant (lea) proteins. these largely disordered proteins protect plants and animals from desiccation. a multitude of studies have characterized stress-protective capabilities of lea proteins in vitro and in heterologous systems. however, the extent to which lea proteins exhibit such functions in vivo, in their native contexts in animals, is unclear. furthermore, little is known about the distribution of lea proteins in multicellular organisms or tissue-specific requirements in conferring stress protection. here, we used the nematode c. elegans as a model to study the endogenous function of an lea protein in an animal. ## Results: We created a null mutant of c. elegans lea-1, as well as endogenous fluorescent reporters of the protein. lea-1 mutant animals formed defective dauer larvae at high temperature. we confirmed that c. elegans lacking lea-1 are sensitive to desiccatio

Who reads LEA motifs promote desiccation tolerance in vivo?

Author

Hibshman, Jonathan D. (author);Goldstein, Bob (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)