Can I read Dose–response Effect of Levetiracetam 1000 and 2000 Mg/day in Partial Epilepsy on EtoBox?

Dose–response Effect of Levetiracetam 1000 and 2000 Mg/day in Partial Epilepsy by P Boon; P Chauvel; B Pohlmann-Eden; C Otoul; S Wroe is a Medicine article available to read on EtoBox.

What is Dose–response Effect of Levetiracetam 1000 and 2000 Mg/day in Partial Epilepsy about?

## Purpose: To evaluate the efficacy, dose-response, tolerability, and withdrawal effects of levetiracetam (keppra) as adjunctive therapy in adult patients with partial epilepsy. ## Methods: In this european multicenter, double-blind, randomized, cross-over trial, levetiracetam 1000 or 2000 mg/day given in two divided doses was compared to placebo as add-on therapy in 324 patients with refractory partial seizures with or without secondary generalization. this trial consisted of six periods: an 8- or 12-week baseline, a treatment period a (4-week titration and 12-week evaluation), a treatment period b (4-week titration and 12-week evaluation), and a withdrawal period. during each evaluation period (a and b), patients received two of the three possible treatment regimens. ## Results: This study provides additional information on dose-response effects and withdrawal phenomena and confirms the responder and seizure freedom rates previously reported in the parallel part of the study (epilepsia 41 (2000) 1179-1186). both doses of levetiracetam significantly decreased mean partial seizure frequency compared with placebo (p or = 50 and > or = 75% reductions in partial seizure frequency (1

Who reads Dose–response Effect of Levetiracetam 1000 and 2000 Mg/day in Partial Epilepsy?

Author

P Boon; P Chauvel; B Pohlmann-Eden; C Otoul; S Wroe

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)

Published

2002

Language

EN

Field

Medicine (Health Sciences)