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Can I read Retention Data from Affinity High-performance Liquid Chromatography in View of Chemometrics on EtoBox?
Retention Data from Affinity High-performance Liquid Chromatography in View of Chemometrics by Roman Kaliszan is a Chemistry article available to read on EtoBox.
What is Retention Data from Affinity High-performance Liquid Chromatography in View of Chemometrics about?
A combination of affinity chromatography and chemometrics is demonstrated to provide information on drug analytes and on biomacromolecules forming stationary phases, which is of relevance to molecular pharmacology and to rational drug design. The approach can also be applied to elucidate the molecular mechanism of enantioseparation on natural biopolymer stationary phases. Affinity high-performance liquid chromatographic data, which were determined on silica-based human serum albumin, a -acid glycoprotein, keratin, collagen, melanin and amylose tris(3,5-dimethylphenylcarbamate) stationary 1 phases, are discussed. Quantitative structure-retention relationships (QSRRs) derived for test series of drug analytes are interpreted in terms of structural requirements of specific binding sites on biomacromolecules. A means to quantify the differences in drug-biomacromolecule binding among the members of analyte families is demonstrated based on hydrophobicity and structural descriptors from molecular modeling. Chemometric processing of appropriately designed sets of affinity chromatographic data may increase the speed and efficiency of a search for new drugs, providing at the same time a chan
Who reads Retention Data from Affinity High-performance Liquid Chromatography in View of Chemometrics?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Roman Kaliszan
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-4347)
- Published
- 1998
- Language
- EN
- Field
- Chemistry (Physical Sciences)