Can I read Quantitative Determination of Noncovalently Bound Acridinium in Protein Conjugates by Liquid Chromatography/electrospray Ion Trap Mass Spectrometry on EtoBox?

Quantitative Determination of Noncovalently Bound Acridinium in Protein Conjugates by Liquid Chromatography/electrospray Ion Trap Mass Spectrometry by Maciej Adamczyk; John C. Gebler; Kevin Shreder; Jiang Wu is a Chemistry article available to read on EtoBox.

What is Quantitative Determination of Noncovalently Bound Acridinium in Protein Conjugates by Liquid Chromatography/electrospray Ion Trap Mass Spectrometry about?

## Abstract A sensitive and robust liquid chromatography/electrospray ion trap mass spectrometry (LC/MS/MS) method has been developed for the quantitative determination of noncovalently bound acridinium free acid in protein‐acridinium conjugates. The lower level of quantitation (LOQ) for acridinium free acid was determined to be 0.6 ng. The assay was validated with a linear concentration range of 0.6–60 ng. The method requires minimum sample handling and is specific, reproducible, and provides a new aspect for protein‐acridinium conjugate characterization. Copyright © 2001 John Wiley & Sons, Ltd.

Who reads Quantitative Determination of Noncovalently Bound Acridinium in Protein Conjugates by Liquid Chromatography/electrospray Ion Trap Mass Spectrometry?

Author

Maciej Adamczyk; John C. Gebler; Kevin Shreder; Jiang Wu

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-4198)

Published

2001

Language

EN

Field

Chemistry (Physical Sciences)