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Measurement of cerebral blood flow in rat brain by ^19^F‐NMR detection of trifluoromethane washout by John A. Detre; Clifford J. Eskey; Alan P. Koretskyp is a Medicine article available to read on EtoBox.

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## Abstract The washout of trifluoromethane (CHF~3~) from rat cerebral cortex was monitored by ^19^F NMR. After 15 min of inhalation of 67% CHF~3~/33% O2 the fluorine signal detected was in a steady state. The CHF~3~ was switched off rapidly at the endotracheal tube and the washout detected with 12‐s time resolution. Two models were used to extract flow information, a simple exponential fit and a model which accounts for arterial CHF~3~ recirculation. In both cases, a two‐compartment model fit the data significantly better than a one‐compartment model. In both models, the faster time component varied with increasing __p__CO~2~, but no significant change in the slow component was detected. At control values of __p__CO~2~, there was a small difference in washout rate constants derived from the two models. At high __p__CO~2~, when tissue washout was comparable to arterial washout of CHF~3~, the model which accounted for arterial recirculation gave higher flows. Using this two‐compartment model with correction for recirculation, a control flow (__p__CO~2~ = 35 mm Hg) of 0.73 ± 0.04 ml/min/g was measured. Increasing plasma __p__CO~2~ increased the apparent flow six‐ to sevenfold with a

Who reads Measurement of cerebral blood flow in rat brain by ^19^F‐NMR detection of trifluoromethane washout?

Author

John A. Detre; Clifford J. Eskey; Alan P. Koretskyp

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

1990

Language

EN

Field

Medicine (Health Sciences)