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Role of O-GlcNAcylation on cancer stem cells: Connecting nutrient sensing to cell plasticity by Giang Le Minh; Mauricio J. Reginato is a book available to read on EtoBox.

What is Role of O-GlcNAcylation on cancer stem cells: Connecting nutrient sensing to cell plasticity about?

Tumor growth and metastasis can be promoted by a small sub-population of cancer cells, termed cancer stem-like cells (CSCs). While CSCs possess capability in self-renewing and differentiating, the hierarchy of CSCs during tumor growth is highly plastic. This plasticity in CSCs fate and function can be regulated by signals from the tumor microenvironment. One emerging pathway in CSCs that connects the alteration in microenvironment and signaling network in cancer cells is the hexosamine biosynthetic pathway (HBP). The final product of HBP, UDP-N-acetylglucosamine (UDP-GlcNAc), is utilized for glycosylating of membrane and secreted proteins, but also nuclear and cytoplasmic proteins by the post-translational modification O-GlcNAcylation. O-GlcNAcylation and its enzyme, O-GlcNAc transferase (OGT), are upregulated in nearly all cancers and been linked to regulate many cancer cell phenotypes. Recent studies have begun to connect OGT and O-GlcNAcylation to regulation of CSCs. In this review, we will discuss the emerging role of OGT and O-GlcNAcylation in regulating fate and plasticity of CSCs, as well as the potential in targeting OGT/O-GlcNAcylation in CSCs.

Author

Giang Le Minh; Mauricio J. Reginato

Publisher

Elsevier Science & Technology

Published

2023

Language

EN

ISBN

9780323991780

Subjects

Science, Comics, Medical