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Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARγ expression and alteration of lipid composition by Hiroyuki Kohno; Yumiko Yasui; Rikako Suzuki; Masashi Hosokawa; Kazuo Miyashita; Takuji Tanaka is a Medicine article available to read on EtoBox.

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## Abstract Our previous short‐term experiment demonstrated that seed oil from bitter melon (__Momordica charantia__) (BMO), which is rich in __cis(c)9__, __trans(t)11__, __t13__‐conjugated linolenic acid (CLN), inhibited the development of azoxymethane (AOM)‐induced colonic aberrant crypt foci (ACF). In our study, the possible inhibitory effect of dietary administration of BMO on the development of colonic neoplasms was investigated using an animal colon carcinogenesis model initiated with a colon carcinogen AOM. Male F344 rats were given subcutaneous injections of AOM (20 mg/kg body weight) once a week for 2 weeks to induce colon neoplasms. They also received diets containing 0.01%, 0.1% or 1% BMO for 32 weeks, starting 1 week before the first dosing of AOM. At the termination of the study (32 weeks), AOM induced 83% incidence (15/18 rats) of colonic adenocarcinoma. Dietary supplementation with 0.01% and 0.1% BMO caused significant reduction in the incidence (47% inhibition by 0.01% BMO, __p__<0.02; 40% inhibition by 0.1% BMO, __p__<0.05; and 17% inhibition by 1% BMO) and the multiplicity (64% inhibition by 0.01% BMO, __p__<0.005; 58% inhibition by 0.1% BMO, __p__<0.02; and 48% i

Who reads Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARγ expression and alteration of lipid composition?

Author

Hiroyuki Kohno; Yumiko Yasui; Rikako Suzuki; Masashi Hosokawa; Kazuo Miyashita; Takuji Tanaka

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2004

Language

EN

Field

Medicine (Health Sciences)