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Can I read ACPA mediates the interplay between innate and adaptive immunity in rheumatoid arthritis on EtoBox?
ACPA mediates the interplay between innate and adaptive immunity in rheumatoid arthritis by Dong, Xiwen; Zheng, Zhaohui; Zhai, Yue; Zheng, Yan; Ding, Jin; Jiang, Jianli; Zhu, Ping is a Medicine article available to read on EtoBox.
What is ACPA mediates the interplay between innate and adaptive immunity in rheumatoid arthritis about?
The production of anti-citrullinated peptide antibodies (ACPAs) requires the participation of both innate immunity and adaptive immunity. On the one hand, activated innate immunity is able to produce citrullinated auto-antigens that fuel autoimmunity and provide an inflammatory environment that facilitates the breach of self-tolerance, proliferation of self-reactive T/B cells and the production of ACPAs. On the other hand, after their production by plasma B cells, ACPAs are also able to interact with innate immunity to exacerbate the manifestation and chronicity of rheumatoid arthritis (RA). This article discusses the roles of citrullinated peptides and ACPA played in innate immunity and autoimmunity. In addition, we emphasise the relationships between environmental factors and innate immunity, as well as the pathogenic function of ACPAs per se. In doing so, we hope to provide fundamental knowledge of RA pathogenesis and reveal potential therapeutic targets in RA treatment.
Who reads ACPA mediates the interplay between innate and adaptive immunity in rheumatoid arthritis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Dong, Xiwen; Zheng, Zhaohui; Zhai, Yue; Zheng, Yan; Ding, Jin; Jiang, Jianli; Zhu, Ping
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1568-9972)
- Published
- 2018
- Language
- EN
- Field
- Medicine (Health Sciences)