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Selective human enterovirus and rhinovirus inhibitors: An overview of capsid-binding and protease-inhibiting molecules by Shin-Ru Shih; Shu-Jen Chen; Gholam Hossein Hakimelahi; Hsing-Jang Liu; Chen-Tso Tseng; Kak-Shan Shia is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The absence of effective vaccines for most viral infections highlights an urgent necessity for the design and development of effective antiviral drugs. Due to the advancement in virology since the late 1980s, several key events in the viral life cycle have been well delineated and a number of molecular targets have been validated, culminating in the emergence of many new antiviral drugs in recent years. Inhibitors against enteroviruses and rhinoviruses, responsible for about half of the human common colds, are currently under active investigation. Agents targeted at either viral protein 1 (VP1), a relatively conserved capsid structure mediating viral adsorption/uncoating process, or 3C protease, which is highly conserved among different serotypes and essential for viral replication, are of great potential to become antipicornavirus drugs. © 2004 Wiley Periodicals, Inc. Med Res Rev, 24, No. 4, 449–474, 2004

Who reads Selective human enterovirus and rhinovirus inhibitors: An overview of capsid-binding and protease-inhibiting molecules?

Author

Shin-Ru Shih; Shu-Jen Chen; Gholam Hossein Hakimelahi; Hsing-Jang Liu; Chen-Tso Tseng; Kak-Shan Shia

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0198-6325)

Published

2004

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)