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Gold Nanoparticles Induced Cloudy Swelling to Hydropic Degeneration, Cytoplasmic Hyaline Vacuolation, Polymorphism, Binucleation, Karyopyknosis, Karyolysis, Karyorrhexis and Necrosis in the Liver by Mohamed Anwar K Abdelhalim; Bashir M Jarrar is a Medicine article available to read on EtoBox.

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## Background Nanoparticles (NPs) can potentially cause adverse effects on organ, tissue, cellular, subcellular and protein levels due to their unusual physicochemical properties. Advances in nanotechnology have identified promising candidates for many biological and biomedical applications. The aim of the present study was to investigate the particle-size, dose and exposure duration effects of gold nanoparticles (GNPs) on the hepatic tissue in an attempt to cover and understand the toxicity and their potential therapeutic and diagnostic use. ## Methods A total of 70 healthy male Wistar-Kyoto rats were exposed to GNPs received 50 or 100 ul of GNPs infusion of size (10, 20 and 50 nm for 3 or 7 days) to investigate particle-size, dose and exposure duration effects of GNPs on the hepatic tissue. ## Results In comparison with respective control rats, exposure to GNPs doses has produced alterations in the hepatocytes, portal triads and the sinusoids. The alterations in the hepatocytes were mainly vacuolar to hydropic degeneration, cytopasmic hyaline vacuolation, polymorphism, binucleation, karyopyknosis, karyolysis, karyorrhexis and necrosis. ## Conclusions The hepatocytes swelling migh

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Author

Mohamed Anwar K Abdelhalim; Bashir M Jarrar

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2002-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1476-511X)

Published

2011

Language

EN

Field

Medicine (Health Sciences)