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Ultrastructural Morphometric Study on the Rat Heart After Chronic Ethanol Feeding by Gerhard Mall; Torsten Mattfeldt; Benedikt Volk is a Medicine article available to read on EtoBox.

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Male Wistar rats were fed with ethanol for 33 weeks. Ethanol was administered in a liquid diet containing 33% of the calories as ethanol. In the control group ethanol was isocalorically replaced by glucose. Light and electron microscopic investigation of the hearts did not indicate significant structural abnormalities, in contrast to the results of some other groups, Nevertheless, morphometric analysis revealed considerable quantitative changes. The number of mitochondria was remarkably reduced and the volume of an average single mitochondrion nearly doubled, whereas the volume fractions of mitochondria and myofibrils were unaltered. The analysis of the mitochondrial subcompartments indicated a slight decrease of the surface area of inner mitochondrial membranes per unit volume of mitochondria and a slight increase of the volume fraction of the mitochondrial matrix space. Myocardial cell hypertrophy or atrophy were not observed. We believe that the mitochondrial changes are the expression of an impaired biogenesis of these organelles. The increased number of capillaries in the ethanol-fed group is possibly caused by functional ethanol effects which may be partly similar to effects

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Author

Gerhard Mall; Torsten Mattfeldt; Benedikt Volk

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1432-2307)

Published

1980

Language

EN

Field

Medicine (Health Sciences)