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Preparation, characterization and preliminary calcium release study of floating sodium alginate/dextran-based hydrogel beads: part I by Sunil Kumar Bajpai; Rasika Tankhiwale is a Materials Science article available to read on EtoBox.

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## Abstract Ionically crosslinked calcium alginate/dextran‐based floating beads were prepared using NaHCO~3~ as porogen. Various micrometric properties such as tapped density, apparent density, compressibility index, etc., were determined for beads with different compositions. The beads were also evaluated for their mechanical strength. The percent buoyancy of the beads was measured as a function of time in simulated gastric fluid (pH = 1.2 at 37 °C). The beads prepared with higher concentrations of NaHCO~3~ porogen and CaCl~2~ crosslinker possessed 100% buoyancy and remained buoyant for nearly 20 h, or even more. Finally, the release of calcium from the beads was observed to follow diffusion‐controlled Higuchi kinetics. Copyright © 2007 Society of Chemical Industry

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Author
Sunil Kumar Bajpai; Rasika Tankhiwale
Publisher
John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0959-8103)
Published
2007
Language
EN
Field
Materials Science (Physical Sciences)

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