Can I read Near-ultraviolet photolysis of β-phenylpyruvic acid generates free radicals and results in DNA damage on EtoBox?

Near-ultraviolet photolysis of β-phenylpyruvic acid generates free radicals and results in DNA damage by A. Hargreaves; F.A. Taiwo; O. Duggan; S.H. Kirk; S.I. Ahmad is a Medicine article available to read on EtoBox.

What is Near-ultraviolet photolysis of β-phenylpyruvic acid generates free radicals and results in DNA damage about?

Ultraviolet A (UVA) light (315-400 nm) is ubiquitously found in our environment and constitutes about 95% of the total solar UV; all UVC and most UVB being absorbed by the stratospheric ozone layer. Compared with UVB and C, UVA does not show any direct effect on biological systems. Indirect effects of UVA, however, have been recognised overwhelmingly and this includes photosensitization of biological and non-biological compounds and production of free radicals many of which include oxygen and are hence known as reactive oxygen species or ROS. Several types of free radicals have been identified although their impacts on various macro- and micro-biomolecules are yet to be fully elucidated. beta-Phenylpyruvic acid is ubiquitously found in eukaryotic cells as a metabolite of phenylalanine, which is subsequently converted to phenyllactate and/or to 2-hydroxyphenylacetate and mandelate. In patients suffering from phenylketonuria the hydroxylation of phenylalanine to tyrosine is defective due to lack of phenylalanine hydroxylase. These result in accumulation and excretion of this compound in the urine. Here we present evidence that photolysis of beta-phenylpyruvic acid by a skin tanning l

Who reads Near-ultraviolet photolysis of β-phenylpyruvic acid generates free radicals and results in DNA damage?

Author

A. Hargreaves; F.A. Taiwo; O. Duggan; S.H. Kirk; S.I. Ahmad

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1011-1344)

Published

2007

Language

EN

Field

Medicine (Physical Sciences)