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Can I read A Proof of Concept Study to Evaluate Putative Benefits of Montelukast in Moderate Persistent Asthmatics on EtoBox?
A Proof of Concept Study to Evaluate Putative Benefits of Montelukast in Moderate Persistent Asthmatics by Graeme P. Currie; Daniel K. C. Lee; Owen J. Dempsey; Stephen J. Fowler; Louise M. Cowan; Brian J. Lipworth is a Medicine article available to read on EtoBox.
What is A Proof of Concept Study to Evaluate Putative Benefits of Montelukast in Moderate Persistent Asthmatics about?
Aims Whether chronic dosing with montelukast confers benefit in patients with moderate to severe asthma remains to be fully established. A proof of concept study was performed evaluating putative benefits with montelukast in moderate persistent asthmatics who were taken off inhaled corticosteroids (ICS) and switched to salmeterol. The latter was done to dissociate the effects of montelukast from ICS. Methods Twenty moderate to severe persistent asthmatics completed a randomized double‐blind crossover study. Subjects received montelukast 10 mg daily or placebo for 2 weeks each. This was preceded by a 2‐week run‐in when ICS were discontinued and salmeterol started, and used on a regular basis throughout the study. Measurements were made after run‐in and after both randomized treatments. Results There were no significant sequence effects for responses as to whether placebo or montelukast were given first or second. Methacholine P__D__~20~ values after run‐in, first and second placebo were 63 μg, 60 μg and 64 μg, respectively (corresponding to 2, 4 and 6 weeks of ICS washout, respectively). Lung function deteriorated pre __vs__ post run‐in, which was significant (__P__ < 0.05) for
Who reads A Proof of Concept Study to Evaluate Putative Benefits of Montelukast in Moderate Persistent Asthmatics?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Graeme P. Currie; Daniel K. C. Lee; Owen J. Dempsey; Stephen J. Fowler; Louise M. Cowan; Brian J. Lipworth
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)