Can I read Polymeric anticancer drugs with pH-controlled activation on EtoBox?
Polymeric anticancer drugs with pH-controlled activation by K Ulbrich; T Etrych; P Chytil; M Pechar; M Jelinkova; B Rihova is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
What is Polymeric anticancer drugs with pH-controlled activation about?
The paper is dealing with the synthesis and properties of new, nontargeted or antibody-targeted pH-sensitive polymer-doxorubicin (DOX) conjugates designed as anticancer drugs facilitating site-specific therapy. These conjugates are stable and inactive during transport in the body but activate inside target cells as a result of pH changes outside and inside the cells. Cytotoxicity of the conjugates depends on the detailed structure of the polymer and of the spacer between the drug and polymer carrier. In both protective and therapeutic regimes of drug administration, the in vivo antitumor activity of the pH-sensitive conjugates containing DOX was significantly enhanced (T-cell lymphoma EL 4, C57BL/16 mice) in comparison with the free DOX or classic PK1, the PHPMA-DOX conjugate clinically tested at present.
Who reads Polymeric anticancer drugs with pH-controlled activation?
It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- K Ulbrich; T Etrych; P Chytil; M Pechar; M Jelinkova; B Rihova
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)
- Published
- 2004
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)