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Design, Synthesis and Biological Evaluation of Hetaryl-nucleoside Derivatives as Inhibitors of Chitin Synthase by Jean-Bernard Behr; Thierry Gourlain; Abdellatif Helimi; Georges Guillerm is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Design, Synthesis and Biological Evaluation of Hetaryl-nucleoside Derivatives as Inhibitors of Chitin Synthase about?

We report here the design, synthesis and biological evaluation of new models of sugar analogues for chitin synthase. These UDP-GlcNAc mimetics associate a sugar-mimicking hetaryl group and uridine, linked with different pyrophosphate bioisosteres. The compounds displayed weak inhibition activity on chitin synthase and their antifungal potencies have been assayed against a large variety of pathogenic fungi.

Who reads Design, Synthesis and Biological Evaluation of Hetaryl-nucleoside Derivatives as Inhibitors of Chitin Synthase?

Author

Jean-Bernard Behr; Thierry Gourlain; Abdellatif Helimi; Georges Guillerm

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)