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Paternal Alcohol Exposure Has Task‐ and Sex‐dependent Behavioral Effect in Offspring by Steven J. Nieto; Mark J. Harding; David A. Nielsen; Therese A. Kosten is a Medicine article available to read on EtoBox.

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## Abstract ## Background Endophenotypes for alcohol use disorder are well known and may reflect paternal exposure effects passed down to offspring via epigenetic mechanisms. Previously, we showed that paternal alcohol exposure prior to conception attenuates the acquisition of operant alcohol self‐administration. We now test whether paternal alcohol exposure alters their offsprings' behavioral responses to alcohol (endophenotypes) and global DNA methylation levels in reward‐related brain regions. ## Methods Adult male rats were exposed to alcohol vapors or air for 6 weeks and mated with alcohol‐naïve females 8 weeks later. Adult male and female offspring of the alcohol‐ and control‐sired litters were tested on three behaviors 30 m after gavage with water or alcohol (1.5 g/kg): open field, elevated plus maze, and accelerating rotarod. Global DNA methylation levels in sperm, nucleus accumbens, and prefrontal cortex were examined in male sires and in another group of offspring. ## Results Alcohol‐sired males showed less anxiety‐like behavior in the elevated plus maze that was not affected by alcohol administration. By contrast, alcohol had anxiolytic effects in the open field in male

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Author

Steven J. Nieto; Mark J. Harding; David A. Nielsen; Therese A. Kosten

Publisher

Wiley

Published

2022

Language

EN

Field

Medicine (Health Sciences)