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Dopaminergic Regulation of Septohippocampal Cholinergic Neurons by Jamie C. Day; Hans C. Fibiger is a Neuroscience article available to read on EtoBox.

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Abstract: The extent to which acetylcholine (ACh) release in the hippocampus is regulated by dopaminergic mechanisms was assessed using in vivo microdialysis in freely moving rats. Systemic administration of the dopamine (DA) receptor agonist apomorphine (1.0 mg/kg) or the specific D~1~ agonist CY 208–243 (1.0 mg/kg) increased microdialysate concentrations of ACh in the hippocampus. The D~2~ receptor agonist quinpirole (0.5 mg/kg) produced a small but statistically significant decrease in hippocampal ACh release. __d__‐Amphetamine (2.0 mg/kg) increased ACh release, an effect that was blocked by the D~1~ receptor antagonist SCH 23390 (0.3 mg/kg) but not by the D~2~ antagonist raclopride (1.0 mg/kg). These findings suggest that endogenous DA stimulates septo‐hippocampal cholinergic neurons primarily via actions at D~1~ receptors. In addition, these results are similar to previous findings regarding the dopaminergic regulation of cortical ACh release, and suggest that the anatomical continuum formed by basal forebrain cholinergic neurons that project to the cortex and hippocampus acts as a functional unit, at least with respect to its regulation by DA.

Who reads Dopaminergic Regulation of Septohippocampal Cholinergic Neurons?

Author

Jamie C. Day; Hans C. Fibiger

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)

Published

1994

Language

EN

Field

Neuroscience (Life Sciences)