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Can I read Melatonin Protects Against Stress‐induced Gastric Lesions by Scavenging the Hydroxyl Radical on EtoBox?
Melatonin Protects Against Stress‐induced Gastric Lesions by Scavenging the Hydroxyl Radical by Debashis Bandyopadhyay; Kausik Biswas; Uday Bandyopadhyay; Russel J. Reiter; Ranajit K. Banerjee is a Neuroscience article available to read on EtoBox.
What is Melatonin Protects Against Stress‐induced Gastric Lesions by Scavenging the Hydroxyl Radical about?
The antiulcer effect of melatonin on gastric lesions caused by restraint‐cold stress or by indomethacin (IMN) was studied with the intent of determining the mechanism of action of the indole. Melatonin dose‐dependently prevents both stress and IMN‐induced gastric damage with around 90% inhibition at a dose of 60 mg per kg BW. When compared with already‐marketed antiulcer drugs, such as ranitidine and omeprazole, melatonin was found to be more effective than ranitidine but less effective than omeprazole in preventing stress ulcer. When compared with other antioxidants, melatonin was more potent than glutathione and essentially equipotent to α‐tocopherol in blocking stress‐induced ulcer. As stress‐induced gastric lesions are mainly caused by oxidative damage due to hydroxyl radicals (OH), the effect of melatonin in scavenging the OH generated during stress conditions, as well as in an in vitro model system, was studied. The results indicate that melatonin at the dose of 60 mg per kg BW caused an 88% reduction of endogenous OH during stress. Melatonin was also highly effective in scavenging OH generated in vitro by a Cu^2+^‐ascorbate system. In this case, melatonin at 100 μM reduced O
Who reads Melatonin Protects Against Stress‐induced Gastric Lesions by Scavenging the Hydroxyl Radical?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Debashis Bandyopadhyay; Kausik Biswas; Uday Bandyopadhyay; Russel J. Reiter; Ranajit K. Banerjee
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0742-3098)
- Published
- 2000
- Language
- EN
- Field
- Neuroscience (Life Sciences)