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Synergy between anti-CCL2 and docetaxel as determined by DW-MRI in a metastatic bone cancer model by Stefan Rozel; Craig J. Galbán; Klaas Nicolay; Kuei C. Lee; Sudha Sud; Chris Neeley; Linda A. Snyder; Thomas L. Chenevert; Alnawaz Rehemtulla; Brian D. Ross; Kenneth J. Pienta is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synergy between anti-CCL2 and docetaxel as determined by DW-MRI in a metastatic bone cancer model about?
## Abstract Metastatic prostate cancer continues to be the second leading cause of cancer death in American men with an estimated 28,660 deaths in 2008. Recently, monocyte chemoattractant protein‐1 (MCP‐1, CCL2) has been identified as an important factor in the regulation of prostate metastasis. CCL2, shown to attract macrophages to the tumor site, has a direct promotional effect on tumor cell proliferation, migration, and survival. Previous studies have shown that anti‐CCL2 antibodies given in combination with docetaxel were able to induce tumor regression in a pre‐clinical prostate cancer model. A limitation for evaluating new treatments for metastatic prostate cancer to bone is the inability of imaging to objectively assess response to treatment. Diffusion‐weighted MRI (DW‐MRI) assesses response to anticancer therapies by quantifying the random (i.e., Brownian) motion of water molecules within the tumor mass, thus identifying cells undergoing apoptosis. We sought to measure the treatment response of prostate cancer in an osseous site to docetaxel, an anti‐CCL2 agent, and combination treatments using DW‐MRI. Measurements of tumor apparent diffusion coefficient (ADC) values were a
Who reads Synergy between anti-CCL2 and docetaxel as determined by DW-MRI in a metastatic bone cancer model?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Stefan Rozel; Craig J. Galbán; Klaas Nicolay; Kuei C. Lee; Sudha Sud; Chris Neeley; Linda A. Snyder; Thomas L. Chenevert; Alnawaz Rehemtulla; Brian D. Ross; Kenneth J. Pienta
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)