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Molecular cloning and characterization of a metal responsive Aedes aegypti intestinal mucin cDNA by A. Rayms‐Keller; M. McGaw; C. Oray; J. O. Carlson; B. J. Beaty is a Agricultural and Biological Sciences article available to read on EtoBox.

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## Abstract We have isolated a cDNA from __Aedes aegypti__ that is transcribed in the larval midgut in response to metal exposure, and in the adult female midgut in response to iron or cadmium exposure, or a blood meal. The cDNA encodes a protein, designated __Aedes aegypti__ intestinal mucin 1 (__AEIMUC__1), which has similarities with invertebrate intestinal mucins and peritrophins, and vertebrate mucins. Proline, serine and threonine comprise 30% of the amino acid composition of __AEIMUC__1, a characteristic of mucins. __AEIMUC__1 contains three cysteine‐rich domains, two of which flank a proline/serine/threonine‐rich domain, a feature shared by many mucin genes. This is the first report on the isolation of a metal‐responsive gene from an aquatic insect.

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Author

A. Rayms‐Keller; M. McGaw; C. Oray; J. O. Carlson; B. J. Beaty

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0962-1075)

Published

2000

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)