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Genetic and environmental interactions on oral cancer in Southern Thailand by Suparp Kietthubthew; Hutcha Sriplung; William W. Au is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Many countries are interested in understanding the relationship between genetic susceptibility and their prevalent environmental cancers for disease prevention. In Thailand we conducted a population‐based case‐control study of 53 matched pairs to assess the risk of oral cancer in relation to genetic polymorphism of the glutathione‐S‐transferase genes (GSTM1 and GSTT1) in cigarette smokers, alcohol drinkers, and betel quid chewers. Interaction of the genes with other potential risk factors such as local bean consumption were also elucidated. Homozygous deletion of GSTM1 has a frequency of 56.6% (n = 30 over 53) among the patients and 30.2% (16/53) among the controls. This gene is associated with a 2.6‐fold higher risk for development of oral cancer (95% CI 1.04–6.5). Among the null GSTM1 individuals, those who smoke, consume alcohol, and/or chew betel quid have a significantly increased risk for oral cancer with an odd ratio (OR) = 4.0 (95% CI = 1.2–13.7), OR = 7.2 (95% CI = 1.5–33.8), and OR = 4.4 (95% CI = 1.1–17.8), respectively. Interactions between any two of the lifestyle habits for oral cancer risk, however, are not found. The frequency of the GSTT1 null genotype

Who reads Genetic and environmental interactions on oral cancer in Southern Thailand?

Author

Suparp Kietthubthew; Hutcha Sriplung; William W. Au

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0893-6692)

Published

2001

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)