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Enhancing Doxorubicin Delivery in Solid Tumor by Superhydrophobic Amorphous Calcium Carbonate–Doxorubicin Silica Nanoparticles with Focused Ultrasound by Pei-Hua Chiang; Ching-Hsiang Fan; Qiaofeng Jin; Chih-Kuang Yeh is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Enhancing Doxorubicin Delivery in Solid Tumor by Superhydrophobic Amorphous Calcium Carbonate–Doxorubicin Silica Nanoparticles with Focused Ultrasound about?

The current approach of delivering chemotherapy pH-sensitive amorphous calcium carbonate-doxorubicin silica nanoparticles (ADS NPs) faces the challenge of insufficient drug dose due to drug instability within the bloodstream and poor tumor penetration. To overcome these long-standing obstacles, we proposed a superhydrophobic coating on the surface of the ADS NPs that could be easily modified fluorination (ADSF NPs). The surface of fluorinated ADS NPs was further modified with a phospholipid layer to reduce aggregation and improve biocompatibility (ADSFL NPs). The contact angle and mean size of ADSFL NPs were 30.2 ± 4.4° and 353.1 ± 54.2 nm, respectively. The superhydrophobic layer generated interfacial nanobubbles on the outer shell of the NPs that reduced water-induced leakage of doxorubicin (DOX) sevenfold compared with the uncoated group and induced a cavitation effect upon ultrasound (US) sonication. Moreover, release of DOX from the ADSFL NPs could be triggered by US, and this release was further improved 1.6-fold in acidic aqueous conditions, indicating that the ADSFL NPs retained pH responsiveness. Enhanced sonography contrast and histological examination demonstrated that U

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Author

Pei-Hua Chiang; Ching-Hsiang Fan; Qiaofeng Jin; Chih-Kuang Yeh

Publisher

American Chemical Society (ACS)

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)