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The document discusses the complexities and methodologies involved in diagnosing androgen deficiency and testosterone replacement therapy, highlighting the importance of accurate measurement techniques for free and bioavailable testosterone. It reviews various assays, including equilibrium dialysis and ultracentrifugation, and addresses the challenges of standardization and variability in testosterone assays across different laboratories. Additionally, it emphasizes the need for reliable reference ranges an

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dzenitaann-b9115

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EN