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Can I read Aspects of intracranial and spinal tumors in patients with Down syndrome and report of a rapidly progressing Grade 2 astrocytoma on EtoBox?
Aspects of intracranial and spinal tumors in patients with Down syndrome and report of a rapidly progressing Grade 2 astrocytoma by Daniel Satg; Pascal Monteil; Annie J. Sasco; Anne Vital; Hiroko Ohgaki; Aim Geneix; Paul Malet; Michel Vekemans; Marie-Odile Rthor is a Medicine article available to read on EtoBox.
What is Aspects of intracranial and spinal tumors in patients with Down syndrome and report of a rapidly progressing Grade 2 astrocytoma about?
## BACKGROUND. Brain tumors in patients with Down syndrome (DS) rarely are reported, and their behavior is not well known. ## METHODS. The authors report on a male patient age 19 years who had DS with diffuse astrocytoma (World Health Organization Grade 2) that recurred twice despite treatment, leading to a glioblastoma and, finally, to death in just over 2 years. The literature on brain tumors in patients with DS is reviewed. ## RESULTS. Although brain neoplasms were suspected to be in excess in patients with DS, the authors found only 36 patients with brain neoplasms and 2 spinal tumors. An unusual distribution of histologic tumor types, with an over-representation of germ cell and mesenchymal tumors and a lack of embryonal tumors, was observed, in agreement with what is known currently about the tumor profile of patients with DS. ## CONCLUSIONS. Cerebral tumors in patients with DS have a specific distribution and may behave differently compared with the general population. These features may be related to the gene dosage effect of oncogenes, antioncogenes, and genes involved in cerebral development due to the supernumerary chromosome 21.
Who reads Aspects of intracranial and spinal tumors in patients with Down syndrome and report of a rapidly progressing Grade 2 astrocytoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Daniel Satg; Pascal Monteil; Annie J. Sasco; Anne Vital; Hiroko Ohgaki; Aim Geneix; Paul Malet; Michel Vekemans; Marie-Odile Rthor
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)