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High-sensitivity-cardiac troponin for accelerated diagnosis of acute myocardial infarction: A systematic review and meta-analysis by Chien-Chang Lee; Sih-Shiang Huang; Yee Hui Yeo; Yi-Ting Hou; James Yeongjun Park; Kenji Inoue; Wan-Ting Hsu is a Medicine article available to read on EtoBox.
What is High-sensitivity-cardiac troponin for accelerated diagnosis of acute myocardial infarction: A systematic review and meta-analysis about?
## Objectives: Cardiovascular disease is the leading cause of mortality and morbidity. serial troponin tests have been endorsed as essential diagnostic steps to rule out/-in acute myocardial infarction (ami), and hs-ctn assays have shown promise in enhancing the accuracy and efficiency of ami diagnosis in the emergency department (ed). ## Methods: A systematic review and meta-analysis of diagnostic test accuracy studies were conducted to compare the diagnostic performance of various accelerated diagnostic algorithms of hs-ctn assays for patients with symptoms of ami. random-effects bivariate meta-analysis was conducted to estimate the summary sensitivity, specificity, likelihood ratios, and area under receiver operating characteristic curve. ## Results: In the systematic review consisting of 56 studies and 67,945 patients, both hs-ctnt and hs-ctni-based 0-, 1-, 2- and 0-1 h algorithms showed a pooled sensitivity >90%. the hs-ctni-based algorithm showed a pooled specificity >80%. the hs-ctnt-based algorithms had a specificity of 68% for the 0-h algorithm and of around 80% for the 1-, 2-, and 0-1 h algorithms. the heterogeneities of all diagnostic algorithms were mild (i < 50%). ## C
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- Author
- Chien-Chang Lee; Sih-Shiang Huang; Yee Hui Yeo; Yi-Ting Hou; James Yeongjun Park; Kenji Inoue; Wan-Ting Hsu
- Publisher
- Elsevier Science; Elsevier ; W. B. Saunders Co., Ltd.; Elsevier BV (ISSN 1532-8171)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)