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Circulating inflammatory cytokines alter transcriptional activity within fibrotic tissue of Dupuytren's disease patients by Mark L. Wang; Ibtesam Rajpar; Nicholas A. Ruggiero; Jolanta Fertala; Andrzej Steplewski; Pedro K. Beredjiklian; Michael R. Rivlin; Yong Chen; George J. Feldman; Andrzej Fertala; Ryan E. Tomlinson is a Medicine article available to read on EtoBox.
What is Circulating inflammatory cytokines alter transcriptional activity within fibrotic tissue of Dupuytren's disease patients about?
Dupuytren's disease is a benign fibroproliferative disorder of the hand that results in disabling digital contractures that impair function and diminish the quality of life. The incidence of this disease has been correlated with chronic inflammatory states, but any direct association between inflammatory cytokines and Dupuytren's disease is not known. We hypothesized that advanced fibroproliferation is associated with increased levels of circulating inflammatory cytokines. Blood and fibrotic cord tissue were collected preoperatively from patients with severe contracture and control patients. Blood plasma concentrations of known inflammatory cytokines were evaluated using a multiplex immunoassay. Proteins from the cord tissue were analyzed by RNA sequencing and immunohistochemistry. Moreover, collagen-rich cords were analyzed using Fouriertransform infrared spectroscopy. The results indicate that patients exhibited significantly elevated circulating inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin (IL)-2, and IL-12p70, as compared with controls. Similarly, IL-4 and IL-13 were detected significantly more frequently in Dupuytren's disease as compared with
Who reads Circulating inflammatory cytokines alter transcriptional activity within fibrotic tissue of Dupuytren's disease patients?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Mark L. Wang; Ibtesam Rajpar; Nicholas A. Ruggiero; Jolanta Fertala; Andrzej Steplewski; Pedro K. Beredjiklian; Michael R. Rivlin; Yong Chen; George J. Feldman; Andrzej Fertala; Ryan E. Tomlinson
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)