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What is Antifungal Tolerance in Candidemia about?

This document discusses antifungal tolerance in Candida albicans, which is distinct from resistance and associated with persistent candidemia. It analyzes tolerance using disk diffusion assays and broth microdilution assays under various conditions. Tolerance is found to depend on stress response pathways like calcineurin and Mkc1 signaling, and the transcription factor Upc2, but not efflux pump regulators. Growth parameters also correlate with tolerance levels.

Author

王麦

Language

EN