About this Neuroscience article

Linarin improves the dyskinesia recovery in Alzheimer's disease zebrafish by inhibiting the acetylcholinesterase activity by Hongye Pan; Jinghui Zhang; Yangyang Wang; Keke Cui; Yueting Cao; Longhu Wang; Yongjiang Wu is a Neuroscience article available to read on EtoBox.

## Background: Due to complex pathogenesis of alzheimer's disease (ad), currently there is no effective disease-modifying treatment. acetylcholinesterase (ache) has introduced itself as an important target for ad therapy. linarin as the representative active ingredient of flavonoid glycoside in flos chrysanthemi indici has been found to have anti-acetylcholinesterase effect. ## Aims: The present study intended to explore the potential effect of linarin for treatment of ad. ## Main methods: In this study, molecular docking simulation was used to evaluate whether linarin could dock with ache and decipher the mechanism of linarin as an ache inhibitor. after molecular docking simulation, alcl-induced alzheimer's disease zebrafish model was established. effects of linarin on treating ad zebrafish dyskinesia and ache inhibition were compared with donepezil (dpz) which was used as a positive control drug. ## Key findings: Molecular docking simulation showed that linarin plays a critical role in ache inhibition by binding ache active sites. the experiments illustrated that the dyskinesia recovery rate of ad zebrafish could be significantly improved by linarin. the dyskinesia recovery and a

Author

Hongye Pan; Jinghui Zhang; Yangyang Wang; Keke Cui; Yueting Cao; Longhu Wang; Yongjiang Wu

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0024-3205)

Published

2019

Language

EN

Field

Neuroscience (Life Sciences)