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Preparation of ( S )‐ibuprofen‐imprinted polymer and its molecular recognition study by Chin‐Yin Hung; Yun‐Tzu Huang; Han‐Hung Huang; Ching‐Chiang Hwang is a Materials Science article available to read on EtoBox.

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## Abstract Two molecularly imprinted polymers (MIPs) were prepared using (__S__)‐ibuprofen as the template molecule as well as methacrylic acid (MAA) or 4‐vinylpyridine and ethylene glycol dimethacrylate (EGDMA) as the functional monomer and crosslinker, respectively. Free radical polymerization was carried out at 4°C under ultraviolet (UV) radiation. The MIPs thus obtained were ground into 25–44 μm, which were slurry packed into analytical columns. The template molecules were removed by acetic acid/methanol solution (1:9, v/v). high‐performance liquid chromatography (HPLC), with UV detection, was used to evaluate the binding performance of the MIP for the template. The selectivity of (__S__)‐ibuprofen and naproxen on the host–guest system were assessed using acetonitrile‐based mobile phases. The limits of detection of ibuprofen and naproxen were found to be 0.1844 mmol/L and 0.3264 mmol/L, while the limits of quantitation were 0.6262 mmol/L and 1.0909 mmol/L, respectively. The stationary phase was applied successfully to the commercial tablet analysis. Ibuprofen and naproxen were extracted from tablets with acetonitrile; analysis results showed a good relative standard deviation

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Author

Chin‐Yin Hung; Yun‐Tzu Huang; Han‐Hung Huang; Ching‐Chiang Hwang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-8995)

Published

2006

Language

EN

Field

Materials Science (Physical Sciences)