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Risk Factors and Anti‐HBc Reactivity among First Time Blood Donors by M. H. J. Molijn; J. M. van der Linden; L. K. Ko; J. Gorgels; W. Hop; D. J. van Rhenen is a Medicine article available to read on EtoBox.

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## Abstract Background and objectives: The usefulness of testing for antibody to hepatitis B core antigen (anti‐HBc) as a surrogate marker for non‐A, non‐B hepatitis can no longer be clearly established in the face of anti‐hepatitis C virus testing. Application of anti‐HBc testing in blood donors for detection of hepatitis B in addition to hepatitis B surface antigen testing (HbsAg) is a matter of debate. Materials and methods: We examined the serology and risk analysis data in a group of first‐time blood donors. In 1.48% of 16,081 donors, anti‐HBc reactivity was found. We invited a study group of 112 donors for extensive interviewing about the risk of blood transmissible diseases, and for serological testing. A control group of 240 first‐time donors was studied as well. Results: In the study group, the age was older (p < 0.001), a history of liver disease was more frequent (p < 0.001), and the donor (p < 0.001) or the donor's partner (p < 0.05) had either stayed longer in an HBV‐endemic area or had been born in one. Combining these with the serological results, we found that strong anti‐HBc reactivity was related to hepatitis B risk factors in HBsAg‐negative donors. Conclusion: An

Who reads Risk Factors and Anti‐HBc Reactivity among First Time Blood Donors?

Author

M. H. J. Molijn; J. M. van der Linden; L. K. Ko; J. Gorgels; W. Hop; D. J. van Rhenen

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0042-9007)

Published

1997

Language

EN

Field

Medicine (Health Sciences)