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Development of a novel dosage form for intramuscular injection of titrated extract of Centella asiatica in a mixed micellar system by Chong-Kook Kim; Yong-Yeon Hwang; Jung Yun Chang; Han-Gon Choi; Soo-Jeong Lim; Mi-Kyung Lee is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
What is Development of a novel dosage form for intramuscular injection of titrated extract of Centella asiatica in a mixed micellar system about?
Titrated extract of Centella asiatica (TECA), a drug used in treating systemic scleroderma, is poorly water-soluble. A conventional dosage form for the intramuscular injection of TECA, propylene glycol (PG)-based TECA solution, causes severe pain after intramuscular injection. To improve the solubility of TECA and reduce pain after injection, mixed micellar systems composed of 10% surfactant mixture (Tween 20 and Tween 85) and 90% phosphate-buffered saline, pH 7.0 (PBS) were prepared. As the ratio of Tween 20 to Tween 85 increased from 0:10 to 10:0, the solubility of TECA in the mixed micellar systems increased from 7-to 26-fold compared to that in PBS (pH 7.0). The droplet size of micelles gradually decreased with the increasing ratio of Tween 20 to Tween 85 from 0:10 to 4:6, followed by an abrupt decrease in size above the ratio of 6:4. Furthermore, the micellar systems prepared with Tween 20 and Tween 85 at the ratio of 6:4, 8:2 or 10:0 could solubilize TECA more than 10 mg/ml and the resultant droplet sizes were less than 2 mm. No significant changes were observed in the droplet sizes and asiaticoside contents in these micellar formulations during storage, indicating these syst
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It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- Chong-Kook Kim; Yong-Yeon Hwang; Jung Yun Chang; Han-Gon Choi; Soo-Jeong Lim; Mi-Kyung Lee
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)
- Published
- 2001
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)