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Can I read The extracts of Astragalus membranaceus overcome tumor immune tolerance by inhibition of tumor programmed cell death protein ligand-1 expression on EtoBox?
The extracts of Astragalus membranaceus overcome tumor immune tolerance by inhibition of tumor programmed cell death protein ligand-1 expression by Chang, Hsu-Liang; Kuo, Yi-Hsuan; Wu, Li-Hsien; Chang, Chih-Min; Cheng, Kai-Jen; Tyan, Yu-Chang; Lee, Che-Hsin is a Medicine article available to read on EtoBox.
What is The extracts of Astragalus membranaceus overcome tumor immune tolerance by inhibition of tumor programmed cell death protein ligand-1 expression about?
A polysaccharide isolated from the radix of __Astragalus membranaceus__, called PG2, used in traditional Chinese medicine, with potential hematopoiesis inducing and immunomodulation activities. PG2 extracted from __A. membranaceus__ has been demonstrated as a novel alternative medicine for cancer patients. Recently, we demonstrated that PG2 enhanced chemotherapy through bystander effect and reduced the expression of indoleamine 2, 3-dioxygenase 1 in tumor cells. Many tumors have been proven to have a high expression of programmed cell death protein ligand-1 (PD-L1), which binds with programmed cell death protein-1(PD-1) in immune cells, thus causing immune tolerance within the tumor microenvironment. With decreased expression of PD-L1, increased immune response can be observed, which might be helpful when developing tumor immunotherapy. The antitumor therapeutic effect mediated by PG2 may associate with an inflammatory immune response at the tumor site. However, the molecular mechanism that by which PG2 inhibits PD-L1 is still incompletely known. The expression of PD-L1 was decreased after tumor cells were treated with PG2. In addition, the cell signaling pathway in tumor cells was
Who reads The extracts of Astragalus membranaceus overcome tumor immune tolerance by inhibition of tumor programmed cell death protein ligand-1 expression?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Chang, Hsu-Liang; Kuo, Yi-Hsuan; Wu, Li-Hsien; Chang, Chih-Min; Cheng, Kai-Jen; Tyan, Yu-Chang; Lee, Che-Hsin
- Publisher
- Ivyspring International Publisher; Blue Haven NSW: Ivyspring International, 2004- (ISSN 1449-1907)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Life Sciences)