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Self-delivery Nanomedicine to Overcome Drug Resistance for Synergistic Chemotherapy by Rong-Rong Zheng; Lin-Ping Zhao; Ling-Shan Liu; Fu-An Deng; Xia-Yun Chen; Xue-Yan Jiang; Chang Wang; Xi-Yong Yu; Hong Cheng; Shi-Ying Li is a Engineering article available to read on EtoBox.

What is Self-delivery Nanomedicine to Overcome Drug Resistance for Synergistic Chemotherapy about?

Multidrug resistance (MDR) is one of the prime reasons for the failure of cancer chemotherapy, which continues to be a great challenge to be solved. In this work, α-tocopherol succinate (α-TOS) and doxorubicin (DOX)-based self-delivery nanomedicine (designated as α-TD) is prepared to combat drug resistance for cancer synergistic chemotherapy. Carrier-free α-TD possesses a fairly high drug loading rate and improves the cellular uptake via the endocytosis pathway. More importantly, the apoptotic inducer α-TOS could elevate the reactive oxygen species (ROS) generation, disrupt mitochondrial function and reduce adenosine 5'-triphosphate (ATP) production, which facilitate the intracellular drug retention while decreasing its efflux. As a result, α-TD achieves a considerable synergistic chemotherapeutic effect against drug resistant cancer cells. Moreover, it also exhibits a preferable inhibitory effect on tumor growth with a low system toxicity in vivo. This synergistic drug self-delivery strategy would open a new window for developing carrier-free nanomedicine for overcoming drug resistance in cancer therapy.

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Author

Rong-Rong Zheng; Lin-Ping Zhao; Ling-Shan Liu; Fu-An Deng; Xia-Yun Chen; Xue-Yan Jiang; Chang Wang; Xi-Yong Yu; Hong Cheng; Shi-Ying Li

Publisher

Royal Society of Chemistry (RSC)

Published

2021

Language

EN

Field

Engineering (Physical Sciences)