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Can I read Hydrogel-forming Microarray Patches with Solid Dispersion Reservoirs for Transdermal Long-acting Microdepot Delivery of a Hydrophobic Drug on EtoBox?
Hydrogel-forming Microarray Patches with Solid Dispersion Reservoirs for Transdermal Long-acting Microdepot Delivery of a Hydrophobic Drug by Yara A. Naser; Ismaiel A. Tekko; Lalitkumar K. Vora; Ke Peng; Qonita K. Anjani; Brett Greer; Christopher Elliott; Helen O. McCarthy; Ryan F. Donnelly is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Hydrogel-forming Microarray Patches with Solid Dispersion Reservoirs for Transdermal Long-acting Microdepot Delivery of a Hydrophobic Drug about?
Hydrogel-forming microarray patches (HF-MAPs) are used to circumvent the skin barrier and facilitate the noninvasive transdermal delivery of many hydrophilic substances. However, their use in the delivery of hydrophobic agents is a challenging task. This work demonstrates, for the first time, the successful transdermal long-acting delivery of the hydrophobic atorvastatin (ATR) via HF-MAPs using poly(ethylene)glycol (PEG)-based solid dispersion (SD) reservoirs. PEG-based SDs of ATR were able to completely dissolve within 90 s in vitro. Ex vivo results showed that 2.05 ± 0.23 mg of ATR/0.5 cm2 patch was delivered to the receiver compartment of Franz cells after 24 h. The in vivo study, conducted using Sprague Dawley rats, proved the versatility of HF-MAPs in delivering and maintaining therapeutically-relevant concentrations (> 20 ng·mL−1) of ATR over 14 days, following a single HF-MAP application for 24 h. The long-acting delivery of ATR suggests the successful formation of hydrophobic microdepots within the skin, allowing for the subsequent sustained delivery as they gradually dissolve over time, as shown in this work. When compared to the oral group, the use of the HF-MAP formulati
Who reads Hydrogel-forming Microarray Patches with Solid Dispersion Reservoirs for Transdermal Long-acting Microdepot Delivery of a Hydrophobic Drug?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yara A. Naser; Ismaiel A. Tekko; Lalitkumar K. Vora; Ke Peng; Qonita K. Anjani; Brett Greer; Christopher Elliott; Helen O. McCarthy; Ryan F. Donnelly
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)