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What is Modified Payne Rearrangement Mechanism about?

This document discusses a modified Payne rearrangement reaction that was developed to efficiently synthesize polyhydroxylated alkaloids. The reaction intercepts the alkoxide intermediate with carbon dioxide, altering the reaction pathway and allowing formation of a 5-membered ring rather than an epoxide. This modification is controlled by temperature and the amount of carbon dioxide used. The new reaction products could serve as scaffolds for biologically active molecules like glycosidase inhibitors.

Author

Zachary Faitz

Language

EN