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Methylation quantitative locus rs3758653 in the DRD4 gene is associated with duration from first heroin exposure to addiction by Rui Zhang; Wei Dang; Jianbo Zhang; Ruifeng He; Guibin Li; Luying Zhang; Zhikang Wang; Hua Zong; Ning Liu; Wei Jia is a Neuroscience article available to read on EtoBox.

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Opioid addiction is a chronic brain disease with a high heritability. However, the genetic underpinnings remain uncertain. DNA methylation is involved in the adaptive changes in neuroplasticity after prolonged drug use. The dopamine receptor D4 (DRD4) has an essential role in the reward processes associated with addictive drugs. To further elucidate the potential role and mechanism of the DRD4 gene variants in heroin addiction, we detected the methylation level of 46 CpG sites in the promoter region and the genotypes of three SNPs in the DRD4 gene. Correlations between the SNPs and methylation levels of the CpG sites, i.e., the analysis of methylation quantitative trait loci (mQTLs) was conducted. Following the identification of mQTLs that are unique in the heroin addiction group, we performed an association study between the mQTLs and traits of heroin addiction. Our results revealed that there were several correlations of SNPs rs3758653 and rs11246226 with the methylation levels of some CpG sites in the DRD4 gene. Among these SNP-CpG pairs, rs3758653-DRD4\_04, rs3758653-DRD4\_05, rs3758653-DRD4\_13 and rs3758653-DRD4\_03 were unique in the heroin addiction group. Moreover, we foun

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Author

Rui Zhang; Wei Dang; Jianbo Zhang; Ruifeng He; Guibin Li; Luying Zhang; Zhikang Wang; Hua Zong; Ning Liu; Wei Jia

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Neuroscience (Life Sciences)