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Can I read Liver Transplantation for Autoimmune Hepatitis and the Success of Aggressive Corticosteroid Withdrawal on EtoBox?
Liver Transplantation for Autoimmune Hepatitis and the Success of Aggressive Corticosteroid Withdrawal by Jeffrey Campsen; Michael A. Zimmerman; James F. Trotter; Michael Wachs; Thomas Bak; Tracy Steinberg; Maria Kaplan; Franklin Wright; Igal Kam is a Medicine article available to read on EtoBox.
What is Liver Transplantation for Autoimmune Hepatitis and the Success of Aggressive Corticosteroid Withdrawal about?
Our center has attempted to minimize corticosteroid (CS) use in all of our orthotopic liver transplantation (OLT) recipients. Because patients with autoimmune hepatitis (AIH) typically require CSs after transplantation, we reviewed our experience in this cohort of patients to determine (1) patient outcomes including recurrent disease and (2) long-term requirements for CS use in AIH patients. From 1988 to 2006, 1102 OLTs were performed in 1032 adult patients at the University of Colorado, of whom 66 (6%) with AIH received 68 allografts. Recurrence was defined by a clinically worsening examination and histological evidence from biopsy. Bivariate and multivariate analyses were used to evaluate predictors of CS withdrawal. Twelve potential predictors of CS discontinuation were considered: age, gender, presence of inflammatory bowel disease (IBD), type of graft (cadaver or living donor), recurrence of AIH, warm ischemia time, follow-up time (time since transplant), and immunosuppressants (cyclosporine, tacrolimus, sirolimus, azathioprine, and mycophenolate mofetil). Overall survival at 5 years was 91%. The 1-and 5-year recurrence-free survival was 88% and 59%, respectively. Risk (incide
Who reads Liver Transplantation for Autoimmune Hepatitis and the Success of Aggressive Corticosteroid Withdrawal?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Jeffrey Campsen; Michael A. Zimmerman; James F. Trotter; Michael Wachs; Thomas Bak; Tracy Steinberg; Maria Kaplan; Franklin Wright; Igal Kam
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)