Can I read Immunogenicity and Safety of Fractional Doses of Yellow Fever Vaccines: a Randomised, Double-blind, Non-inferiority Trial on EtoBox?

Immunogenicity and Safety of Fractional Doses of Yellow Fever Vaccines: a Randomised, Double-blind, Non-inferiority Trial by Aitana Juan-Giner; Derick Kimathi; Kyra H Grantz; Mainga Hamaluba; Patrick Kazooba; Patricia Njuguna; Gamou Fall; Moussa Dia; Ndeye S Bob; Thomas P Monath; Alan D Barrett; Joachim Hombach; Edgar M Mulogo; Immaculate Ampeire; Henry K Karanja; Dan Nyehangane; Juliet Mwanga-Amumpaire; Derek A T Cummings; Philip Bejon; George M Warimwe; Rebecca F Grais is a Social Sciences article available to read on EtoBox.

What is Immunogenicity and Safety of Fractional Doses of Yellow Fever Vaccines: a Randomised, Double-blind, Non-inferiority Trial about?

## Background: Stocks of yellow fever vaccine are insufficient to cover exceptional demands for outbreak response. fractional dosing has shown efficacy, but evidence is limited to the 17dd substrain vaccine. we assessed the immunogenicity and safety of one-fifth fractional dose compared with standard dose of four who-prequalified yellow fever vaccines produced from three substrains. ## Methods: We did this randomised, double-blind, non-inferiority trial at research centres in mbarara, uganda, and kilifi, kenya. eligible participants were aged 18-59 years, had no contraindications for vaccination, were not pregnant or lactating, had no history of yellow fever vaccination or infection, and did not require yellow fever vaccination for travel. eligible participants were recruited from communities and randomly assigned to one of eight groups, corresponding to the four vaccines at standard or fractional dose. the vaccine was administered subcutaneously by nurses who were not masked to treatment, but participants and other study personnel were masked to vaccine allocation. the primary outcome was proportion of participants with seroconversion 28 days after vaccination. seroconversion was

Who reads Immunogenicity and Safety of Fractional Doses of Yellow Fever Vaccines: a Randomised, Double-blind, Non-inferiority Trial?

Author

Aitana Juan-Giner; Derick Kimathi; Kyra H Grantz; Mainga Hamaluba; Patrick Kazooba; Patricia Njuguna; Gamou Fall; Moussa Dia; Ndeye S Bob; Thomas P Monath; Alan D Barrett; Joachim Hombach; Edgar M Mulogo; Immaculate Ampeire; Henry K Karanja; Dan Nyehangane; Juliet Mwanga-Amumpaire; Derek A T Cummings; Philip Bejon; George M Warimwe; Rebecca F Grais

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Social Sciences