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Polymorphic Crystal Forms and Cocrystals in Drug Delivery (Crystal Engineering) by Shan, Ning (author);Zaworotko, Michael J. (author) is a scholarly article available to read on EtoBox.

What is Polymorphic Crystal Forms and Cocrystals in Drug Delivery (Crystal Engineering) about?

Active pharmaceutical ingredients, APIs, are most conveniently developed and delivered orally as solid dosage forms that contain a defined crystalline form of an API. This means that the pharmacokinetic profile of a dosage form is at the very least linked to the physicochemical properties of the crystal form that is selected for development. Furthermore, that crystal forms of new chemical entities are novel, lack obviousness, and have utility makes them patentable. Therefore, selection of a specific crystal form for a given API is a profoundly important step in drug development from clinical, legal, and regulatory perspectives. In this context, scientific developments that afford greater understanding of and diversity in the number of crystalline forms available for a given API, which have traditionally been limited to salts, polymorphs, and hydrates/solvates [1], are obviously of relevance to the pharmaceutical industry. The science of crystal engineering [2] focuses upon self-assembly of existing molecules or ions and it has evolved in such a manner that a wide range of new crystal forms can be generated without the need to invoke covalent-bond breakage or formation. This contrib

Author

Shan, Ning (author);Zaworotko, Michael J. (author)

Publisher

Wiley

Published

2021

Language

EN