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Can I read A Stress Response Pathway That Enhances Hematopoietic Stem Cell Longevity Promotes Acute Myeloid Leukemia Growth and Progression on EtoBox?
A Stress Response Pathway That Enhances Hematopoietic Stem Cell Longevity Promotes Acute Myeloid Leukemia Growth and Progression by Yoon Joon Kim; Kentson Lam; Fanny Zhou; Carlo M Ong; Jeffrey A. Magee; Robert Signer is a Medicine article available to read on EtoBox.
What is A Stress Response Pathway That Enhances Hematopoietic Stem Cell Longevity Promotes Acute Myeloid Leukemia Growth and Progression about?
Aging is the single biggest risk factor for the development of cancer. This association has historically been attributed to the fact that rate limiting genetic mutations accumulate over time. However, many other hallmarks of aging can convey selective advantages that may ultimately promote the development of cancer. We recently discovered that aging hematopoietic stem cells (HSCs) activate Heat shock factor 1 (HSF1), a key transcriptional regulator that dynamically remodels the protein homeostasis (proteostasis) network upon acute and chronic proteotoxic stress. HSF1 activation promotes HSC fitness and proteostasis maintenance during aging. Several high-risk leukemogenic mutations tend to arise disproportionately in older adults, but whether HSF1 confers fitness advantages to acute myeloid leukemia (AML) cells is untested. We found that HSF1 is highly expressed across multiple human AML cell lines harboring distinct mutational profiles, and that it is readily activated in response to stress. CRISPR-Cas9 mediated deletion of HSF1 significantly reduced AML cell growth and proliferation in vitro. Furthermore, HSF1-deficiency severely impaired AML progression and significantly extended
Who reads A Stress Response Pathway That Enhances Hematopoietic Stem Cell Longevity Promotes Acute Myeloid Leukemia Growth and Progression?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Yoon Joon Kim; Kentson Lam; Fanny Zhou; Carlo M Ong; Jeffrey A. Magee; Robert Signer
- Publisher
- American Society of Hematology
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)