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Evaluation of Anti-Diarrheal Activity of 80% Methanol Extracts of Vernonia amygdalina Delile (Asteraceae) Leaves in Mice by Mosisa Gudeta, Biruk; Melesie Taye, Getu; Abula, Teferra; Alemayehu Gadisa, Diriba is a Medicine article available to read on EtoBox.
What is Evaluation of Anti-Diarrheal Activity of 80% Methanol Extracts of Vernonia amygdalina Delile (Asteraceae) Leaves in Mice about?
## Introduction Diarrhea is a cause of morbidity and mortality, especially in children. Patients with diarrhea have been suffering from limited treatment options due to poor drug tolerance, side effect, and multi-drug resistance to almost all the current drug treatments. Therefore, it is important to search for a new therapeutic medicine that can effectively prevent the disease and safe. __Vernonia amygdalina__ is an indigenous medicinal plant used traditionally for the treatment of diarrhea in Ethiopia. The aim of this study was therefore to confirm the antidiarrheal activities of 80% methanol leaves extract using mice models. ## Materials and Methods The antidiarrheal activities of the 80% methanol leaves extract were investigated using castor oil-induced diarrhea, intestinal motility, and enteropooling models in mice. The negative control received distilled water orally, the test groups received three dose levels (100, 200, and 400 mg/kg) of the plant materials, and the positive control is given 3 mg/kg Loperamide orally. ## Results In the castor oil-induced diarrheal model, the extract delayed onset of diarrhea and reduced fecal parameters at all tested doses significantly as c
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- Author
- Mosisa Gudeta, Biruk; Melesie Taye, Getu; Abula, Teferra; Alemayehu Gadisa, Diriba
- Publisher
- Dove Press Ltd.; Dove Medical Press; Dove Medical Press Ltd.; Informa UK Limited (ISSN 1179-1454)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Life Sciences)