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High Recovery Rate of Consciousness by High‐volume Filtrate Hemodiafiltration for Fulminant Hepatitis by Keiichi Fujiwara; Ryuzo Abe; Shin Yasui; Osamu Yokosuka; Naoya Kato; Shigeto Oda is a Medicine article available to read on EtoBox.

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## Aim An artificial liver support (ALS) system sustaining patients with acute liver failure (ALF) in good condition until recovery of the native liver or performance of liver transplantation (LT), is essential for the improvement of the poor prognosis of ALF despite the lack of survival benefit. We aimed to investigate the efficacy of various ALS systems for fulminant hepatitis (FH) carried out in our liver unit so far, focusing on the restoration of consciousness from hepatic encephalopathy. ## Methods One hundred and ten consecutive adult Japanese patients with FH admitted to Chiba University Hospital (Chiba, Japan) between 1988 and 2016 who received ALS were analyzed. ## Results Recovery rate of consciousness improved with the increased dialysate flow rate and filtrate rate: 37.5% by plasma exchange (PE), 51.9% by PE + continuous hemodiafiltration (CHDF), 57.7% by slow PE (sPE) + high‐flow CHDF (HFCHDF) (Q~D~ = 300 mL/min), 88.6% by HFCHDF (Q~D~ = 500 mL/min) (+ sPE), and 92.9% by on‐line HDF (OLHDF) (+ sPE). All patients except one, who could not be fully treated because of circulatory failure, recovered consciousness by OLHDF, including those whose liver function were complet

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Author

Keiichi Fujiwara; Ryuzo Abe; Shin Yasui; Osamu Yokosuka; Naoya Kato; Shigeto Oda

Publisher

Wiley

Published

2018

Language

EN

Field

Medicine (Health Sciences)