About this Medicine article
Central retina changes in Parkinson’s disease: a systematic review and meta-analysis by Huang, Lele; Zhang, Dan; Ji, Jianling; Wang, Yujie; Zhang, Ruijun is a Medicine article available to read on EtoBox.
## Background and purpose: Central retina imaging is important for early parkinson's disease (pd) recognition. we aimed to investigate central retina changes using spectral domain-optical coherence tomography (sd-oct) in pd patients. ## Methods: We systematically searched pubmed and embase to identify studies comparing the whole or individual layer thickness of central retina between pd patients and health controls using sd-oct from inception to april 25, 2020. data were extracted at eye level. we pooled the mean difference with random effects model. subgroup analysis and mete-regression were done to detect possible source of heterogeneity. ## Results: We included 27 studies (28 sets of data) enrolling 1470 pd patients (2288 eyes) and 1552 health controls (2524 eyes) in our meta-analysis. compared with control eyes, the whole thickness of central retina decreased significantly at fovea center by mean difference - 2.70 μm (95% ci [- 4.87, - 0.53], p = 0.01) and in all quadrants in pd eyes. the combination of ganglion cell layer and inner plexiform layer thinned by an average mean difference of - 3.17 μm (95% ci [- 5.07, - 1.26], p = 0.001). the nerve fiber layer thinned by an averag
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- Author
- Huang, Lele; Zhang, Dan; Ji, Jianling; Wang, Yujie; Zhang, Ruijun
- Publisher
- Springer; Springer-Verlag; Dr. Dietrich Steinkopff Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0340-5354)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)