Can I read Enhanced Invasiveness and Metastatic Potential of Epithelial Cell Lines Cultured in the Presence of Dimethyl Sulphoxide on EtoBox?

Enhanced Invasiveness and Metastatic Potential of Epithelial Cell Lines Cultured in the Presence of Dimethyl Sulphoxide by Jacqueline M. Bentel; Gregory C. Rhodes; Irit Markus; Garry J. Smith is a Medicine article available to read on EtoBox.

What is Enhanced Invasiveness and Metastatic Potential of Epithelial Cell Lines Cultured in the Presence of Dimethyl Sulphoxide about?

Several passage cycles of poorly metastatic malignant epithelial cells through immunosuppressed mice failed to induce enhanced metastasis-forming ability of cells derived from either the primary subcutaneous tumours or the resultant lung metastases. In vitro treatment of cultured malignant cells with dimethyl sulphoxide (DMSO) induced a reversible change in phenotype towards increased invasiveness but did not significantly increase metastasis formation. A cloned-cell line from a spontaneous in vitm transformant in the presence of DMSO was highly invasive and hi hly metastatic. In vitro treatment of cultured cells with 22 (vh) DMSO produced alterations in morphology with decreased growth rate of all cell lines and decreased anchorage-independent colony formation in several malignant cell lines. All in vitro and in vivo effects were reversible following both short-and long-term (I year) culture of cells in the presence of DMSO, suggesting epigenetic effects. These data support the concept of independent genetic controls for the invasiveness of tumours and the ability to form metastases.

Who reads Enhanced Invasiveness and Metastatic Potential of Epithelial Cell Lines Cultured in the Presence of Dimethyl Sulphoxide?

Author

Jacqueline M. Bentel; Gregory C. Rhodes; Irit Markus; Garry J. Smith

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1990

Language

EN

Field

Medicine (Health Sciences)