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Mycobacterium Tuberculosis Infection and Laboratory Diagnosis in Solid-organ Transplant Recipients by Cengiz Cavusoglu; Candan Cicek-Saydam; Zeki Karasu; Yeser Karaca; Mehmet Ozkahya; Hüseyin Toz; Yaman Tokat; Altinay Bilgic is a Medicine article available to read on EtoBox.

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Tuberculosis (TB) is an unusual infection in transplant recipients. We evaluated (i) the frequency of TB, (ii) the duration to develop the TB infection, and (iii) clinical consequences, in 380 solid‐organ recipients from January 1995 to December 2000. A total of 10 (2.63%) patients (eight renal, two liver transplant recipients) were found to have post‐transplantation TB. The frequency of TB in this patient population is 8.5‐fold higher than the prevalance in the general Turkish population. Tuberculosis developed within 2–33 months after transplantation, with a median of 15 months. In all of these 10 patients, __Mycobacterium tuberculosis__ (MTB) was isolated from the culture. All the patients continued to have low dose immunosuppressive treatment, and also quadriple antituberculosis treatment [isoniazid (INH), rifampin (RIF), pyrazinamide (PRZ) and ethambutol (ETB)] has been given. The two recipients had died of disseminated form of TB. Relapse was detected in one patient 6 months after the completion of the treatment. As post‐transplant TB infection develops mostly within the first year after transplantation, clinicians should be more careful for early and fast diagnosis and treat

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Author

Cengiz Cavusoglu; Candan Cicek-Saydam; Zeki Karasu; Yeser Karaca; Mehmet Ozkahya; Hüseyin Toz; Yaman Tokat; Altinay Bilgic

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0902-0063)

Published

2002

Language

EN

Field

Medicine (Health Sciences)