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Effects of levodopa and subthalamic nucleus stimulation on cognitive and affective functioning in Parkinson's disease by Aurélie Funkiewiez; Claire Ardouin; Roshan Cools; Paul Krack; Valérie Fraix; Alina Batir; Stephan Chabardès; Alim-Louis Benabid; Trevor W. Robbins; Pierre Pollak is a Medicine article available to read on EtoBox.
What is Effects of levodopa and subthalamic nucleus stimulation on cognitive and affective functioning in Parkinson's disease about?
## Abstract In Parkinson's disease (PD), levodopa and subthalamic nucleus (STN) stimulation lead to major improvement in motor symptoms. Effects of both treatments on cognition and affective status are less well understood. Motor, cognitive, and affective symptoms may relate to the dysfunctioning of parallel cortico–striatal loops. The aim of this study was to assess cognition, behavior, and mood, with and without both treatments in the same group of PD patients. A group of 22 nondemented PD patients was included in this study. Patients were tested twice before surgery (__off__ and __on__ levodopa) and twice 3 months after surgery (OFF and ON STN stimulation, __off__ levodopa). Cognitive and affective effects of STN stimulation and levodopa had some common, but also different, effects. STN stimulation improved performance on the planning test, associated with the dorsolateral prefrontal cortex. However, the treatments had opposite effects on tests associated with the orbitofrontal cortex; specifically, levodopa impaired while STN stimulation improved performance on the extinction phase of a reversal/extinction task. Acutely, both treatments improved motivation and decreased fatigue
Who reads Effects of levodopa and subthalamic nucleus stimulation on cognitive and affective functioning in Parkinson's disease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Aurélie Funkiewiez; Claire Ardouin; Roshan Cools; Paul Krack; Valérie Fraix; Alina Batir; Stephan Chabardès; Alim-Louis Benabid; Trevor W. Robbins; Pierre Pollak
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)