Opening book details…
Can I read Cumulative Evaluation of a Quantitative Immunochemical Fecal Occult Blood Test to Determine Its Optimal Clinical Use on EtoBox?
Cumulative Evaluation of a Quantitative Immunochemical Fecal Occult Blood Test to Determine Its Optimal Clinical Use by Paul Rozen; Doron Comaneshter; Zohar Levi; Rachel Hazazi; Alex Vilkin; Eran Maoz; Shlomo Birkenfeld; Yaron Niv is a Medicine article available to read on EtoBox.
What is Cumulative Evaluation of a Quantitative Immunochemical Fecal Occult Blood Test to Determine Its Optimal Clinical Use about?
## Abstract ## BACKGROUND: Quantified, human hemoglobin (Hb)‐specific, immunochemical fecal occult blood test (IFOBT) measurements are now used for colorectal cancer (CRC) screening. The objective was to evaluate sensitivity and specificity for CRC and advanced adenomatous polyps (APs) by the fecal Hb threshold used to determine a positive test and the number of IFOBTs prepared per test, so as to determine the least number of colonoscopies required to detect a neoplasm. ## METHODS: Cumulative data were analyzed from a prospective cross‐sectional double‐blind study of 1682 consecutive, ambulatory, nonbleeding colonoscopy patients who volunteered for IFOBTs, most of above average risk, from 3 ambulatory‐endoscopy centers. Fecal Hb was measured in 3 samples and analyzed by an automated instrument, and the highest result ≥50 ng Hb/mL of buffer was related to findings. ## RESULTS: Colonoscopy identified CRC in 20 patients and advanced APs in 129. Sensitivity for either was best when any of 3 tests had ≥50 ng Hb/mL of buffer; sensitivity was 61.1% (95% confidence interval [CI], 53.2‐68.9), and specificity was 87.8% (95% CI, 86.2‐89.4). Positive tests identified 100% of CRCs and 55% of ad
Who reads Cumulative Evaluation of a Quantitative Immunochemical Fecal Occult Blood Test to Determine Its Optimal Clinical Use?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Paul Rozen; Doron Comaneshter; Zohar Levi; Rachel Hazazi; Alex Vilkin; Eran Maoz; Shlomo Birkenfeld; Yaron Niv
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)