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This document discusses the structure and function of topoisomerases, which are enzymes that solve topological problems associated with DNA replication, transcription, and recombination. It describes the two main types of topoisomerases - type I enzymes cleave one DNA strand while type II enzymes cleave both strands. Both form covalent intermediates with DNA. Topoisomerases are important for processes like relaxing supercoils and decatenating DNA strands. The document also examines the mechanism of type II

Author

Ankeet Kumar

Language

EN