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Can I read TRALI after the infusion of marrow cells in a patient with acute lymphoblastic leukemia on EtoBox?
TRALI after the infusion of marrow cells in a patient with acute lymphoblastic leukemia by Norinaga Urahama; Ryuji Tanosaki; Kami Masahiro; Kimiko Iijima; Aki Chizuka; Sung‐Won Kim; Akiko Hori; Rie Kojima; Osamu Imataki; Atsushi Makimito; Shin Mineishi; Yoichi Takaue is a Medicine article available to read on EtoBox.
What is TRALI after the infusion of marrow cells in a patient with acute lymphoblastic leukemia about?
**BACKGROUND:** TRALI is one of the most serious, life‐threatening complications after blood transfusion. Antibodies against neutrophils or HLA molecules from the donor are thought to be the primary causative agents. Rarely, antibodies in the recipient may react with transfused neutrophils and initiate the same events, which raises the possibility that TRALI may also occur in an allogeneic PBPC transplantation setting. **CASE REPORT:** A 30‐year‐old Japanese man with acute lymphoblastic leukemia developed TRALI immediately after the infusion of marrow cells from an unrelated donor. The infusion was suspended, and he gradually improved after receiving steroids and oxygen support. The next day, the remaining cells, which were separated to MNCs, were infused with no reactions. He then recovered over 5 days without the use of mechanical ventilation. **RESULTS:** Laboratory evaluation disclosed the presence of antibodies to neutrophils in his sera sampled after transplantation, but not in the donor's marrow graft. Hence, antibodies to neutrophils in the recipient may have reacted with neutrophils in the graft and contributed to the development of TRALI. **CONCLUSION:** This is the first
Who reads TRALI after the infusion of marrow cells in a patient with acute lymphoblastic leukemia?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Norinaga Urahama; Ryuji Tanosaki; Kami Masahiro; Kimiko Iijima; Aki Chizuka; Sung‐Won Kim; Akiko Hori; Rie Kojima; Osamu Imataki; Atsushi Makimito; Shin Mineishi; Yoichi Takaue
- Publisher
- Elsevier Science; John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Elsevier; Elsevier BV; Wiley (ISSN 0372-1248)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)